Title:
ファージディスプレイにより同定されたヒト及びマウスのターゲティングペプチド
Document Type and Number:
Japanese Patent JP5591209
Kind Code:
B2
Abstract:
The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, including but not limited to gene therapy vectors. A novel class of gene therapy vectors is disclosed. Certain of the disclosed peptides have therapeutic use for inhibiting angiogenesis, inhibiting tumor growth, inducing apoptosis, inhibiting pregnancy or inducing weight loss. Methods of identifying novel targeting peptides in humans, as well as identifying endogenous receptor-ligand pairs are disclosed. Methods of identifying novel infectious agents that are causal for human disease states are also disclosed. A novel mechanism for inducing apoptosis is further disclosed.
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Inventors:
アラップ ワディ
Path カリニ レナタ
Path カリニ レナタ
Application Number:
JP2011245272A
Publication Date:
September 17, 2014
Filing Date:
November 09, 2011
Export Citation:
Assignee:
Board オブ リージエンツ, the university オブ Texas system
International Classes:
C12N15/09; A61K31/225; A61K31/23; A61K31/56; A61K31/683; A61K31/685; A61K31/688; A61K31/713; A61K35/12; A61K35/76; A61K38/00; A61K39/00; A61K39/02; A61K39/12; A61K39/395; A61K45/00; A61K47/42; A61K47/48; A61K48/00; A61K49/00; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P13/02; A61P19/02; A61P25/28; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P43/00; C07K1/04; C07K5/08; C07K5/10; C07K7/04; C07K7/06; C07K7/08; C07K14/00; C07K14/005; C07K14/47; C07K14/52; C07K16/00; C07K16/08; C07K16/18; C07K19/00; C12N7/02; C12N15/10; C12N15/861; C12N15/864; C12Q1/02; C12Q1/70; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Spring water Original aim