Title:
フペルジンA誘導体、その製造およびその使用
Document Type and Number:
Japanese Patent JP4105592
Kind Code:
B2
Abstract:
The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is or R'' and Y together form =CH; R is (C1-C5) alkyl, wherein n is 0 or 1, X is H, (C1-C5) alkyl; (C1-C5) alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis-(C1-C5) alkyl; -(CH2)mCOOZ, wherein m=0-5, Z is H or (C1-C5) alkyl; -CH=CH-G, wherein G is phenyl, furanyl, carboxy, alkyloxycarbonyl; and dihydro- or tetrahydro-pyridyl substituted by (C1-C5) alkyl at the nitrogen atom; R' is H, (C1-C5) alkyl, pyridoyl, benzoyl substituted by (C1-C5) alkyloxy; R'' is H or (C1-C5) alkyl; processes for their use as acetylcholinesterase inhibitor.
Inventors:
Chu Ta Yuan
Tan Si Tsang
Lin Ching Lai
Chow
Shen Jin Kang
Ukoan Sung
Tian Shan Hao
Takuji Yamaguchi
Kazuhiro Tanaka
Takeshi Wakamatsu
Hiroaki Nishimura
Tan Si Tsang
Lin Ching Lai
Chow
Shen Jin Kang
Ukoan Sung
Tian Shan Hao
Takuji Yamaguchi
Kazuhiro Tanaka
Takeshi Wakamatsu
Hiroaki Nishimura
Application Number:
JP2003148129A
Publication Date:
June 25, 2008
Filing Date:
May 26, 2003
Export Citation:
Assignee:
Shanghai Institute of Materia Medica Chinese Academy of Sciences
Chu Ta Yuan
Tan Si Tsang
Lin Ching Lai
Chow
Shen Jin Kang
Ukoan Sung
Tian Shan Hao
Chu Ta Yuan
Tan Si Tsang
Lin Ching Lai
Chow
Shen Jin Kang
Ukoan Sung
Tian Shan Hao
International Classes:
C07D221/22; A61K31/435; A61K31/439; A61K31/44; A61K31/4427; A61K31/443; A61K31/444; A61K31/4748; A61K36/18; A61P21/00; A61P25/28; C07D401/06; C07D401/12; C07D401/14; C07D405/12
Other References:
Zhongguo Yaoli Xuebao,第15巻,第2号,pp.107-110,1994年3月
Attorney, Agent or Firm:
Takashi Ishida
Yoshio Yoshio
Masaya Nishiyama
Yoshio Yoshio
Masaya Nishiyama