HYBRID MONOCLONAL ANTIBODY HAVING DOUBLE SPECIFICITY

Title:

HYBRID MONOCLONAL ANTIBODY HAVING DOUBLE SPECIFICITY

Document Type and Number:

Japanese Patent JPH0279970

Kind Code:

A

Abstract:

PURPOSE: To eliminate need for operation to chemically bind an antibody to toxin molecules by preparing a polydoma capable of producing a hybrid monoclonal antibody having specificity for human lymphotoxin in one thereof and for tumor-related antigens on cancerous cell surface membranes in the other.

CONSTITUTION: The objective hybrid monoclonal antibody, having double specificity and obtained by fusing an antihuman lymphotoxin antibody-producing hybridoma to an antibody-producing hybridoma against human transferrin receptors frequently expressed on cancerous cell surface membranes and using the resultant tetraoma.

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Inventors:

IWASA SUSUMU
TOYODA YUKIO
KONDO KOICHI

Application Number:

JP23148588A

Publication Date:

March 20, 1990

Filing Date:

September 17, 1988

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Assignee:

TAKEDA CHEMICAL INDUSTRIES LTD

International Classes:

C12N5/10; A61K39/395; A61P35/00; C07K14/00; C07K14/52; C07K14/525; C07K14/705; C07K16/00; C07K19/00; C12N5/16; C12P21/08; C12R1/91; (IPC1-7): A61K39/395; C07K15/12; C12N5/16; C12P21/08

Attorney, Agent or Firm:

Akitoshi Otawa (1 outside)

Next Patent: PRIMARY STRUCTURE OF HUMAN GAMMA-GLUTAMYL TRANSPEPTIDASE