Title:
エリスロマイシン塩の水和物、その製造方法及び使用
Document Type and Number:
Japanese Patent JP2011527292
Kind Code:
A
Abstract:
The present invention relates to a macrolide derivative as well as preparation and use thereof. The macrolide derivative of the present invention, i.e., a hydrate of erythromycin salts, has a molecular formula of C 37 H 67 NO 13 ·A·nH 2 O, n=1.0-11.0, in which A is an organic acid or an organic acids, selected from lactobionic acid, thiocyanic acid, maleic acid, fumaric acid, thiocyanic acid, acetic acid, methanesulfonic acid, benzenesulfonic acid, nicotinic acid, lactic acid, citric acid, tartaric acid, aspartic acid, glutamic acid and phosphoric acid, the hydrate has good water solubility and better storage stability, which is suitable for the manufacture of a medicament for the treatment and prophylaxis of infectious diseases in human or animal caused by Gram-positive or negative bacteria.
Inventors:
Liu, Lee
Application Number:
JP2011516951A
Publication Date:
October 27, 2011
Filing Date:
July 10, 2009
Export Citation:
Assignee:
Liu, Lee
International Classes:
C07H17/08; A61K31/7048; A61P31/00; C07C59/08; C07C59/265; C07D213/80; C07H15/06
Foreign References:
| US2761859A | 1956-09-04 | |||
| US4137397A | 1979-01-30 | |||
| GB1013837A | 1965-12-22 | |||
| US2791531A | 1957-05-07 | |||
| US3637654A | 1972-01-25 |
Other References:
JPN7013004688; 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ｌａｃｔｏｂｉｏｎａｔｅｓ ｏｆ ａｌｋａｌｉｎｅ ａｎｔｉｂｉｏｔｉｃｓ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．６１, 1964, １４７７０-１４７７１欄
JPN7013004690; 'Ｌａｃｔｏｂｉｏｎｉｃ ａｃｉｄ ａｎｄ ｉｔｓ ｓａｌｔｓ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．７０, 1969, ｐ．６２９
JPN6011009592; 杉本功 外: '溶媒和物，非晶質固体と医薬品製剤' 粉体工学会誌 Ｖｏｌ．２２， Ｎｏ．２, 1985, ｐ．８５（１５）-９７（２７）
JPN6009059501; 薬剤学マニュアル 第１版, 19890320, ｐ．２８, 株式会社南山堂
JPN7013004692; 'Ｅｒｙｔｈｒｏｍｙｃｉｎ ｐｏｌｙｍｏｒｐｈｉｓｍ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．６５, 1966, １８４２６欄
JPN7013004695; 'Ｐｈｙｓｉｃａｌ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ａｎｄ ｄｉｓｓｏｌｕｔｉｏｎ ｂｅｈａｖｉｏｒ ｏｆ ｖａｒｉｏｕｓ ｃｒｙｓｔａｌ ｆｏｒｍｓ ｏｆ ｅｒｙｔｈｒｏｍｙｃｉｎ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．１０４, 1986, ｐ．３５７
JPN7013004696; 'Ｉｎｖｅｓｔｉｇａｔｉｏｎ ｏｆ ｅｒｙｔｈｒｏｍｙｃｉｎ ｍｏｎｏｈｙｄｒａｔｅ ａｎｄ ｄｉｈｙｄｒａｔｅ ｂｙ ＩＲ ｓｐｅｃｔｒａ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．１０５, 1986, ｐ．３１８
JPN7013004698; 'Ｐｈｙｓｉｃａｌ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ｅｒｙｔｈｒｏｍｙｃｉｎ： ａｎｈｙｄｒａｔｅ， ｍｏｎｏｈｙｄｒａｔｅ， ａｎｄ ｄｉｈｙｄｒａｔｅ ｃｒｙｓｔａｌｌｉｎｅ ｓｏｌｉｄｓ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．８９, 1978, ｐ．３５１
JPN6010003282; '医薬品の残留溶媒ガイドラインについて' 医薬審第３０７号 , 1998
JPN7013004690; 'Ｌａｃｔｏｂｉｏｎｉｃ ａｃｉｄ ａｎｄ ｉｔｓ ｓａｌｔｓ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．７０, 1969, ｐ．６２９
JPN6011009592; 杉本功 外: '溶媒和物，非晶質固体と医薬品製剤' 粉体工学会誌 Ｖｏｌ．２２， Ｎｏ．２, 1985, ｐ．８５（１５）-９７（２７）
JPN6009059501; 薬剤学マニュアル 第１版, 19890320, ｐ．２８, 株式会社南山堂
JPN7013004692; 'Ｅｒｙｔｈｒｏｍｙｃｉｎ ｐｏｌｙｍｏｒｐｈｉｓｍ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．６５, 1966, １８４２６欄
JPN7013004695; 'Ｐｈｙｓｉｃａｌ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ａｎｄ ｄｉｓｓｏｌｕｔｉｏｎ ｂｅｈａｖｉｏｒ ｏｆ ｖａｒｉｏｕｓ ｃｒｙｓｔａｌ ｆｏｒｍｓ ｏｆ ｅｒｙｔｈｒｏｍｙｃｉｎ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．１０４, 1986, ｐ．３５７
JPN7013004696; 'Ｉｎｖｅｓｔｉｇａｔｉｏｎ ｏｆ ｅｒｙｔｈｒｏｍｙｃｉｎ ｍｏｎｏｈｙｄｒａｔｅ ａｎｄ ｄｉｈｙｄｒａｔｅ ｂｙ ＩＲ ｓｐｅｃｔｒａ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．１０５, 1986, ｐ．３１８
JPN7013004698; 'Ｐｈｙｓｉｃａｌ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ｅｒｙｔｈｒｏｍｙｃｉｎ： ａｎｈｙｄｒａｔｅ， ｍｏｎｏｈｙｄｒａｔｅ， ａｎｄ ｄｉｈｙｄｒａｔｅ ｃｒｙｓｔａｌｌｉｎｅ ｓｏｌｉｄｓ' Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．８９, 1978, ｐ．３５１
JPN6010003282; '医薬品の残留溶媒ガイドラインについて' 医薬審第３０７号 , 1998
Attorney, Agent or Firm:
Michiharu Soga
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Kazuhiro Oyaku