Title:
ヒドロコドンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体、そのプロドラッグ、製造法及び使用
Document Type and Number:
Japanese Patent JP5442862
Kind Code:
B2
Abstract:
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
Inventors:
Mikuru, Travis
Gunther, Sven
Mikuru, Crystal
Chi, Guo Chen
Kansky, Yaroslow
Martin Kay, Martin
Bella, Bindu
Gunther, Sven
Mikuru, Crystal
Chi, Guo Chen
Kansky, Yaroslow
Martin Kay, Martin
Bella, Bindu
Application Number:
JP2012518606A
Publication Date:
March 12, 2014
Filing Date:
July 01, 2010
Export Citation:
Assignee:
ChemFarm Incorporated
International Classes:
A61K31/485; A61K9/02; A61K9/08; A61K9/10; A61K9/14; A61K9/20; A61K9/48; A61P25/04; A61P25/36; A61P43/00; C07D489/02
Domestic Patent References:
| JP2005524648A | ||||
| JP10509167A |
Foreign References:
| US20080090771 | ||||
| WO2008051759A1 |
Other References:
Arzneimittel-Forschung,1993年,Vol.43, No.11,p.1200-1203
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Go Kajita
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Go Kajita