Title:
水素化方法
Document Type and Number:
Japanese Patent JP3598133
Kind Code:
B2
Abstract:
The present invention relates to a novel, catalytic process for the preparation of optically active compounds of the general formula in which R<1> and R<2> in a position other than the alpha - or ss-position represent alkyl which is optionally interrupted by an O atom or optionally substituted benzyl, R<3> is hydrogen, lower alkyl, optionally substituted benzyl, -CO-R<4>, -COOR<4> or -CONR@, and R<4> denotes a lower alkyl or aryl, by subjecting a compound of the general formula in which R<1>, R<2> and R<3> have the abovementioned meaning to an asymmetric hydrogenation in the presence of a complex of an optically active, preferably atropisomeric, diphosphine ligand with a metal of Group VIII.
Inventors:
Emile Alvin Broger
Martin Calpe
Ulrich Zutter
Martin Calpe
Ulrich Zutter
Application Number:
JP21642594A
Publication Date:
December 08, 2004
Filing Date:
September 09, 1994
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
B01J31/22; C07B53/00; C07B57/00; C07B61/00; C07D309/32; C07D309/34; (IPC1-7): C07D309/32; B01J31/22; C07B53/00; C07B57/00
Attorney, Agent or Firm:
Hajime Tsukuni
Mutsuo Watanabe
Mutsuo Watanabe