Title:
ヒドロラーゼ、それをコードする核酸並びにその製造および使用方法
Document Type and Number:
Japanese Patent JP4829105
Kind Code:
B2
Abstract:
The disclosure provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the disclosure is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the disclosure include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). The polypeptides of the disclosure can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals. In another aspect, the polypeptides of the disclosure are used to synthesize enantiomerically pure chiral products.
Inventors:
Bornshore Uwe
Weiner David Paul
Hitchman tim
Ryan Jonathan
Wonthakuru Cyril
Weiner David Paul
Hitchman tim
Ryan Jonathan
Wonthakuru Cyril
Application Number:
JP2006509241A
Publication Date:
December 07, 2011
Filing Date:
March 08, 2004
Export Citation:
Assignee:
Verenium Corporation
International Classes:
C12N15/09; A01H5/00; A01K67/027; A23C7/00; A23C9/20; A23C19/05; A23C19/06; A23D7/00; A23K1/16; A23K20/189; A23L1/00; A23L1/30; A23L29/00; A23L33/17; A23L33/195; A61K6/00; A61K8/37; A61K8/60; A61K8/66; A61K31/7088; A61K31/7105; A61K38/00; A61K38/46; A61Q5/06; A61Q11/00; A61Q19/00; C07H21/00; C07H21/02; C07K16/40; C07K19/00; C10M129/70; C10M129/76; C10M177/00; C11D3/386; C11D7/42; C11D17/06; C11D17/08; C12C1/047; C12C5/00; C12C11/00; C12M1/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/14; C12N9/16; C12N9/18; C12N9/20; C12N11/00; C12N11/02; C12N11/14; C12N11/16; C12N15/10; C12N15/55; C12N15/82; C12P7/52; C12P7/62; C12P7/64; C12P19/34; C12P21/02; C12P21/08; C12P41/00; C12Q1/02; C12Q1/34; C12Q1/68; C12S11/00; D06M15/00; D06M16/00; G01N33/573; A61K
Domestic Patent References:
| JPH0246280A | 1990-02-15 | |||
| JP2001504327A | 2001-04-03 |
Foreign References:
| US5089395A | 1992-02-18 | |||
| WO2002020735A2 | 2002-03-14 | |||
| WO2002057411A2 | 2002-07-25 |
Attorney, Agent or Firm:
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Gen Tashiro
Atsushi Hakoda
Kenji Asai
Gen Tashiro