To obtain a hydroxamic acid derivative having a gelatinase-inhibiting action and useful for the therapy of rheumatism, etc.
This compound of formula I [R1 is H, a 1-4C alkyl; R2 is H, a 1-8C alkyl, etc.; E is -CO-NR3 (R3 is H, a 1-4C alkyl, etc.; A is H, a 1-8C alkyl, etc.; J is a single bond, a 2-4C alkylene, etc.; G is -(CH2)m- (m is 2, 3, 4), etc.; but the compound wherein E is O-CO-NR3-, -O-CO-O, -O-CS-NR3-, or -O-CS-O-; j is a single bond; and A is H is excluded]. For example, a compound of formula II. A compound of formula V (Ar substituent in A1, and R6, R7 in G1 are not each COOH, amino, hydroxyl group, etc.; A1-J1-E1- is not -CS-OH; and R2-A is a 1-8C alkyl, phenyl, a 1-4C alkyl replaced with a phenyl group) as the example of the compound of formula I is obtained by reacting a compound of formula III with a compound of formula VI.
KANAZAWA HIDEKAZU
SUGIURA TSUNEYUKI
MIYAZAKI TORU
ONO HIROYUKI
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