To obtain a new hydroxamic derivative having an excellent matrix metalloproteinase-inhibiting activity, good in oral absorbability and useful as a medicine for inhibiting the metastasis, infiltration and proliferation of various kinds of cancer cells or as a medicine for treating or preventing hypertrophic arthritis and rheumatic arthritis.
A compound of formula I [R1 is a 1-15C alkyl which may have as substituent such as a 1-6C alkoxy or a 3-8C cycloalkyl; R2 is H, hydroxy, a 1-4C aliphatic acyloxy; R3 is a 1-6C alkyl which may have a substituent such as a hydroxy or a 1-4C alkoxy; R4 is H, a 2-5C alkoxycarbonyl, etc.; R5 is H, a 1-4C alkyl; R6 is H, a 1-6C aliphatic acyl which may be substituted with an amino group, etc. ] and its pharmacologicaly acceptable salt. For example, N4-hydroxy-N1-[1-hydroxymethyl-2,2-dimethylpropyl]-2-nonylsuccinamide. The compound of formula I is obtained by repeatedly subjecting a compound of formula II and a compound of formula III as starting raw materials to condensation reactions and protecting group-removing reactions.
OKAWA NOBUYUKI
TAKEMOTO TOSHIYASU
SATO SUSUMU
TAMAKI KAZUHIKO
KURIHARA NOBUKAZU
TANZAWA KAZUHIKO
KOBAYASHI TOMOO
MIURA SHINICHI
