Title:
Hydroxyalkylalkylcellulose for tableting and solid preparations containing it
Document Type and Number:
Japanese Patent JP6318103
Kind Code:
B2
Abstract:
Provided are a hydroxyalkylalkyl cellulose excellent in formability and not causing marked delay in disintegration when added even in a small amount; a solid preparation comprising the hydroxyalkylalkyl cellulose; and a method for producing the solid preparation. More specifically, provided are a hydroxyalkylalkyl cellulose for tableting having a specific surface area of from 0.5 to 5.0 m 2 /g as measured by BET and a solid preparation comprising the hydroxyalkylalkyl cellulose. Also provided is a method for producing the hydroxyalkylalkyl cellulose for tableting, comprising the steps of: bringing pulp into contact with an alkali metal hydroxide solution to obtain an alkali cellulose, reacting the alkali cellulose with an etherifying agent to obtain a first hydroxyalkylalkyl cellulose, grinding the first hydroxyalkylalkyl cellulose, and subjecting the ground first hydroxyalkylalkyl cellulose to hydrolysis in the presence of an acid catalyst or oxidative degradation in the presence of an oxidant to obtain a second hydroxyalkylalkyl cellulose.
Inventors:
Yokozawa Takuya
Naosuke Maruyama
Naosuke Maruyama
Application Number:
JP2015026553A
Publication Date:
April 25, 2018
Filing Date:
February 13, 2015
Export Citation:
Assignee:
Shin-Etsu Chemical Co., Ltd.
International Classes:
A61K9/20; C08B11/08; A61K47/38
Domestic Patent References:
| JP2008133258A |
Foreign References:
| WO1992003167A1 |
Other References:
Mitchell, K. et al.,International Journal of Pharmaceutics,1993年,vol.100,p.175-179
Attorney, Agent or Firm:
Mitsuo Matsui
Hidefumi Kawamura
Hidefumi Kawamura
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