Title:
ヒストンデアセチラーゼ(HDAC)の阻害活性を有するヒドロキシアミド化合物
Document Type and Number:
Japanese Patent JP4946861
Kind Code:
B2
Abstract:
Compounds having the formula (I): wherein R1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s), R2 is hydrogen or lower alkyl, X is pyrrolidinylene or piperidinylene, Y is pyridylene, which may be substituted with one or more suitable substituent(s), Z is lower alkenylene, which may be substituted with lower alkyl or halogen, and salts thereof are useful as a histone deacetylase inhibitors.
Inventors:
Naoki Ishibashi
Yuki Sawada
Taiji Urano
Shigeki Sato
Inoue Zen Ladies
Permanent Yoshiteru
Koichiro Kokichi
Ikki Kamijo
Fumiyuki Shirai
Hisashi Takasugi
Yuki Sawada
Taiji Urano
Shigeki Sato
Inoue Zen Ladies
Permanent Yoshiteru
Koichiro Kokichi
Ikki Kamijo
Fumiyuki Shirai
Hisashi Takasugi
Application Number:
JP2007504193A
Publication Date:
June 06, 2012
Filing Date:
August 08, 2005
Export Citation:
Assignee:
Astellas Pharma Inc.
International Classes:
C07D401/12; A61K31/167; A61K31/40; A61K31/427; A61K31/44; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4709; A61K31/497; A61K31/501; A61K31/506; A61P1/00; A61P1/02; A61P1/16; A61P3/06; A61P3/10; A61P5/00; A61P7/00; A61P7/02; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/14; A61P19/00; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P31/04; A61P35/00; A61P35/02; A61P37/02; A61P37/08; A61P43/00; C07C259/06; C07D207/14; C07D213/74; C07D401/14; C07D403/12; C07D405/14; C07D409/14; C07D417/12; C07D417/14
Domestic Patent References:
| JP2003514904A | ||||
| JP2004509105A |
Foreign References:
| WO2004024160A1 | ||||
| WO2004043352A1 | ||||
| WO2003075839A1 |
Attorney, Agent or Firm:
Morita Taku
Emiko Yano
鈴木 ▲頼▼子
Hamai Kosuke
Emiko Yano
鈴木 ▲頼▼子
Hamai Kosuke