Title:
HIVインテグラーゼ阻害薬として有用なヒドロキシナフチリジノンカルボキサミド類
Document Type and Number:
Japanese Patent JP4523281
Kind Code:
B2
Abstract:
Hydroxynaphthyridinone carboxamides of formula: are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein L, R1a, R1b, R1c, R2a, R2b, R3, R4, and R5 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.
Inventors:
Egbertson, Melitsa
Melamed, Jeffrey Wye
Langford, H. Marie
Young, Stephen Day
Melamed, Jeffrey Wye
Langford, H. Marie
Young, Stephen Day
Application Number:
JP2003562086A
Publication Date:
August 11, 2010
Filing Date:
January 13, 2003
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07D471/04; A61K31/4353; A61K31/4375; A61K31/496; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61K31/541; A61K45/00; A61K45/06; A61P31/18; A61P43/00; C07D471/02
Domestic Patent References:
| JP6271570A | ||||
| JP5503532A | ||||
| JP6502845A |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura