Title:
11β-ヒドロキシステロイドデヒドロゲナーゼ1型化活性化合物
Document Type and Number:
Japanese Patent JP4629657
Kind Code:
B2
Abstract:
The use of substituted amides for modulating the activity of 11²-hydroxysteroid dehydrogenase type 1 (11²HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11²HSD1 and may be useful in the treatment, prevention and/or prophylaxis of a range of medical disorders where a decreased intracellular concentration of active glucocorticoid is desirable.
Inventors:
Gundel Tofte, Annette
Jorgensen, Anchor Steen
Campen, Gita Camila Tail Girl
Andersen, Henrik Sneh
Christensen, Inge Sogar
Kilburn, John Paul
Jorgensen, Anchor Steen
Campen, Gita Camila Tail Girl
Andersen, Henrik Sneh
Christensen, Inge Sogar
Kilburn, John Paul
Application Number:
JP2006504355A
Publication Date:
February 09, 2011
Filing Date:
April 06, 2004
Export Citation:
Assignee:
High Point Pharmaceuticals,LLC
International Classes:
C07D209/02; A61K31/16; A61K31/415; A61K45/06; A61P3/04; A61P3/10; A61K31/55; A61P1/00; A61P1/04; A61P1/08; A61P1/14; A61P1/16; A61P3/00; A61P3/06; A61P3/14; A61P5/10; A61P5/14; A61P5/38; A61P7/00; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P15/08; A61P15/10; A61P17/14; A61P19/02; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P39/02; A61P43/00; C07D209/08; C07D401/12; C07D403/12; C07D487/04
Domestic Patent References:
| JP4154765A |
Foreign References:
| WO2004065351A1 | ||||
| WO2002094799A1 | ||||
| WO2003029245A1 | ||||
| WO2001032621A1 | ||||
| WO2001022969A1 | ||||
| US5468858 | ||||
| WO2004089416A1 | ||||
| WO2004089415A1 | ||||
| WO2004089470A1 |
Other References:
J. Molecular Catalysis B: Enzymatic,2003年 1月16日,21,97-105
Chem. Lett.,1993年,757-760
Polymer J.,1988年,20,615-625
Magnetic Resonance in Chemistry,1985年,23,506-513
Heterocycles,1985年,23,317-323
Farmaco Edizione Scientifica,1981年,36,237-250
J. Med. Chem.,1979年,22,1142-1144
Chem. Lett.,1993年,757-760
Polymer J.,1988年,20,615-625
Magnetic Resonance in Chemistry,1985年,23,506-513
Heterocycles,1985年,23,317-323
Farmaco Edizione Scientifica,1981年,36,237-250
J. Med. Chem.,1979年,22,1142-1144
Attorney, Agent or Firm:
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Tetsuya Kazama
Katsumura Hiro
Shoji Kawai
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori
Takuzo Ichihara
Yamashita Gen
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Tetsuya Kazama
Katsumura Hiro
Shoji Kawai
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori
Takuzo Ichihara
Yamashita Gen