Title:
低酸素誘導性因子αのムテインおよびその使用方法
Document Type and Number:
Japanese Patent JP2005508607
Kind Code:
A
Abstract:
The present invention provides hypoxia inducible factor alpha muteins, DNA sequences encoding these hypoxia inducible factor alpha muteins, recombinant DNA molecules containing those DNA sequences operatively linked to expression control sequences and capable of inducing expression of an hypoxia inducible factor alpha muteins, hosts transformed with those recombinant DNA molecules, pharmaceutical compositions containing hypoxia inducible factor alpha muteins and methods of using those compositions to treat hypoxia and ischemic related tissue damage.
Inventors:
Kaerin, William G.
Ivan, Millsea
Ivan, Millsea
Application Number:
JP2002574369A
Publication Date:
April 07, 2005
Filing Date:
March 20, 2002
Export Citation:
Assignee:
Dana-Farber Cancer Institute Incorporated
International Classes:
C12N15/09; A61K38/00; A61K38/02; A61K38/17; A61K38/44; A61K48/00; A61P9/00; A61P17/02; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/26; G01N33/573; (IPC1-7): C12N15/09; A61K38/00; A61K48/00; A61P9/00; A61P17/02; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita