ICOS LIGAND VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF

Title:

ICOS LIGAND VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF

Document Type and Number:

Japanese Patent JP2022064959

Kind Code:

A

Abstract:

To provide therapeutic compositions for modulating immune response in the treatment of cancer and immunological diseases.SOLUTION: Provided herein are immunomodulatory proteins comprising ICOSL variants and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.SELECTED DRAWING: Figure 13A

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Inventors:

RYAN SWANSON
MICHAEL KORNACKER

Application Number:

JP2022012270A

Publication Date:

April 26, 2022

Filing Date:

January 28, 2022

Export Citation:

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Assignee:

ALPINE IMMUNE SCIENCES INC

International Classes:

C12N15/12; A61K35/12; A61K35/15; A61K35/17; A61K35/76; A61K35/761; A61K35/763; A61K35/765; A61K35/766; A61K35/768; A61K38/16; A61K45/00; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P9/00; A61P11/00; A61P11/02; A61P11/04; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/08; A61P21/00; A61P25/00; A61P27/02; A61P27/16; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P37/06; C07K14/705; C07K16/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/01; C12N15/13; C12N15/62; C12N15/63; C12N15/85; C12N15/86

Domestic Patent References:

JP2013518900A	2013-05-23
JP7058609B2	2022-04-22
JP2019514361A	2019-06-06

Other References:

J. IMMUNOL., vol. 177, JPN6021021607, 2006, pages 3920 - 3929, ISSN: 0005110253

Attorney, Agent or Firm:

Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto

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