Title:
IL-21 antagonist
Document Type and Number:
Japanese Patent JP6027849
Kind Code:
B2
Abstract:
Monoclonal antibodies are identified that bind the IL-21 protein. These antibodies are used to identify regions of the IL-21 protein to where binding neutralizes IL-21 activity. Hybridomas and methods of producing anti-IL-21 monoclonal antibodies are described. The monoclonal antibodies are useful in treating IL-21-mediated diseases, which may include autoimmune and inflammatory diseases such as pancreatitis, type I diabetes (IDDM), Graves Disease, inflammatory bowel disease (IBD), Crohn's Disease, ulcerative colitis, irritable bowel syndrome, multiple sclerosis, rheumatoid arthritis, diverticulosis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, scleroderma, systemic sclerosis, psoriatic arthritis, osteoarthritis, atopic dermatitis, vitiligo, graft vs. host disease (GVHD), cutaneous T cell lymphoma (CTCL), Sjogren's syndrome, glomerulonephritis, IgA nephropathy, graft versous host disease, transplant rejection, atopic dermatitis, anti-phospholipid syndrome, and asthma, and other autoimmune diseases.
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Inventors:
Shiva Kumar Parawl Buoy.
Jaspers Stephen Earl.
Jaspers Stephen Earl.
Application Number:
JP2012235520A
Publication Date:
November 16, 2016
Filing Date:
October 25, 2012
Export Citation:
Assignee:
Zymogenetics, Incorporated
International Classes:
C12N15/02; A61K39/395; A61P1/04; A61P1/18; A61P3/10; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P19/08; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P37/06; C07K16/24; C12N5/10; C12N15/09; C12P21/08
Domestic Patent References:
| JP2002537839A |
Other References:
小野田正志他,「抗ヒトIL-21単クロン抗体を用いたIL-21発現解析の試み」,第35回日本免疫学会総会・学術集会講演要旨集,2005年11月15日,第286ページ
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Ryuichi Inoue
Masato Ozeki