Title:
【発明の名称】マルチ・ドラッグ耐性のモジュレーターとしての1-アミノ-3-フェノキシ-プロパン誘導体
Document Type and Number:
Japanese Patent JPH08508270
Kind Code:
A
Abstract:
This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: 1 (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.
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Inventors:
Janssen, Bernd
Clink, Andreas
Muller, Stephan
Ritter, Kurt
Shreker, liner
Kyle Howell, Gerhard
Romander, Cynthia
Traugot, Ulrich
Clink, Andreas
Muller, Stephan
Ritter, Kurt
Shreker, liner
Kyle Howell, Gerhard
Romander, Cynthia
Traugot, Ulrich
Application Number:
JP52161694A
Publication Date:
September 03, 1996
Filing Date:
March 19, 1994
Export Citation:
Assignee:
BSF Actien Gezel Shaft
International Classes:
C07D295/08; A61K31/34; A61K31/341; A61K31/357; A61K31/36; A61K31/40; A61K31/403; A61K31/41; A61K31/42; A61K31/421; A61K31/4245; A61K31/425; A61K31/426; A61K31/433; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4412; A61K31/4418; A61K31/445; A61K31/451; A61K31/47; A61K31/495; A61K31/496; A61P35/00; C07D207/333; C07D209/52; C07D211/14; C07D213/30; C07D215/14; C07D261/08; C07D261/18; C07D263/14; C07D263/32; C07D271/06; C07D271/10; C07D277/24; C07D285/12; C07D295/092; C07D307/42; C07D307/58; C07D317/58; C07D317/66; C07D333/06; C07D333/16; C07D413/12; C07D417/12; C07D521/00; C07F9/6509; C07D207/32; (IPC1-7): C07D207/333; A61K31/34; A61K31/36; A61K31/40; A61K31/41; A61K31/42; A61K31/425; A61K31/44; A61K31/445; A61K31/47; A61K31/495; C07D209/52; C07D211/14; C07D213/30; C07D215/14; C07D261/08; C07D263/32; C07D271/10; C07D277/24; C07D285/12; C07D295/08; C07D307/42; C07D307/58; C07D317/66; C07D333/06; C07D333/16; C07D413/12; C07D521/00
Attorney, Agent or Firm:
Toshio Yano (2 outside)