Title:
【発明の名称】1,2-二置換ベンゼンカルボキサミド誘導体及び養毛剤、皮膚外用剤
Document Type and Number:
Japanese Patent JP2982873
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new compound useful e.g. as a hair tonic and a preparation for external use for skin, having excellent hair development-stimulating effects and hair-growing effects. SOLUTION: This derivative is expressed by formula I [out of A and B, one is a 10-20C hydrocarbon and another is a (CH2 )n -NR<2> R<3> (R<2> and R<3> are each H, a lower alkyl or the like); Z is O, OCO or the like; R<4> is a halogen, lower alkyl, lower acyl or the like; R<5> is H, a lower alkyl, lower acyl, lower alkylcarbamoyl or the like; (m) is 0 or 1; (n) is 0-5], for example, [2-(hydroxymethyl) phenyl]-N-octadecylformamide. This derivative is obtained e.g. by reacting a phthalide of formula II with an amine of formula III and reacting the resultant compound with an amine of formula IV (R<6> is H, a lower alkyl, lower acyl or the like) in the presence of an additive such as pyridine in a solvent such as chloroform at a temp. of -15 deg.C to room temperature.
Inventors:
FUKUNISHI HIROTADA
UMISHIO KENICHI
TAJIMA MASAHIRO
KOBAYASHI KOJI
UMISHIO KENICHI
TAJIMA MASAHIRO
KOBAYASHI KOJI
Application Number:
JP29881398A
Publication Date:
November 29, 1999
Filing Date:
October 20, 1998
Export Citation:
Assignee:
SHISEIDO KK
International Classes:
A61K8/00; A61K8/30; A61K8/42; A61K8/49; A61K31/00; A61K31/415; A61K31/4164; A61K31/495; A61K31/496; A61K31/535; A61K31/5375; A61P17/00; A61P17/14; A61Q5/00; C07D295/04; A61Q5/02; A61Q7/00; C07C271/12; C07C271/20; C07C281/02; C07D233/61; C07D295/16; C07D295/22; (IPC1-7): C07C271/12; A61K7/00; A61K7/06; A61K31/00; A61K31/415; A61K31/495; A61K31/535; C07C271/20; C07C281/02; C07D233/61; C07D295/04; C07D295/16; C07D295/22
Attorney, Agent or Firm:
Yuji Iwahashi