Title:
【発明の名称】癌治療に有用な17位置換ステロイド
Document Type and Number:
Japanese Patent JP2742331
Kind Code:
B2
Abstract:
Compounds of the general formula (1> wherein X represents the residue of the A, B and C rings of a steroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R<14> represents a hydrogen atom a halogen atom or an alkyl group of 1-4 carbon atoms and R<15> represents a hydrogen atom or an alkyl or alkoxy group of 1-4 carbon atoms, or a hydroxy or alkylcarbonyloxy group of 2 to 5 carbon atoms or together represent an oxo or methylene group or R<14> R<15> together represent a double bond and the other R<15> represent hydrogen or alkyl of 1-4 carbon atoms, and R<16> represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, in the form of the free bases or pharmaceutically acceptable acid addition salts, with the proviso that 17-(3- pyridyl)androsta-5,14,16-trien-3 beta -o1 and 15 beta -acetoxy-17-(3-pyridyl)androsta-5, 15,dien-3 beta -o1 and their 3-acetates and 3 beta - methoxy-17-(3-pyridyl)androst-16-ene are claimed only for use in therapy are useful for treatment of androgen-dependent disorders, especially prostatic cancer, and also oestrogen-dependent disorders such as breast cancer.
Inventors:
Barry, Susan Elaine
Michael Jearman
Potter, The Errored Andrew
Michael Jearman
Potter, The Errored Andrew
Application Number:
JP51718793A
Publication Date:
April 22, 1998
Filing Date:
March 15, 1993
Export Citation:
Assignee:
Brititsushi Technology Group Limited
International Classes:
A61P35/00; C07J13/00; A61K31/58; C07J31/00; C07J41/00; C07J43/00; C07J51/00; (IPC1-7): C07J43/00; A61K31/58
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)