Title:
【発明の名称】ビタミンDの17―側鎖アルキニル―および20―オキソプレグナ―誘導体、その製法および医薬組成物
Document Type and Number:
Japanese Patent JP2000503636
Kind Code:
A
Abstract:
1-Hydroxy pregnacalciferol derivatives of formula (I) and their corresponding 5,6-trans isomers wherein R1 is hydroxyl or lower alkoxy and R2 is optionally hydroxylated or lower alkoxylated lower alkynyl or R1 is C(RA) (RB)CH3 where RA is optionally hydroxylated or lower alkoxylated lower alkynyl and RB is hydroxyl or lower alkoxy or RA and RB together represent oxo and R2 is hydrogen, hydroxyl or lower alkoxy, and R3 and R4 represent hydrogen atoms, exhibit anti-progesterone activity and may be useful as antineoplastic, antifertility, antiproliferative, immunosuppressive and/or antiinflammatory agents.
Inventors:
Hets, robert henry
Pettiett, Maurice Murdsk
Settei, Sundara, Kurt Yugam, Siniversa Settsu
Pettiett, Maurice Murdsk
Settei, Sundara, Kurt Yugam, Siniversa Settsu
Application Number:
JP52343397A
Publication Date:
March 28, 2000
Filing Date:
December 23, 1996
Export Citation:
Assignee:
Research institute for far medicine and chemistry incorporated
International Classes:
A61K31/00; A61K31/593; A61P15/00; A61P29/00; A61P35/00; A61P37/00; A61P37/06; A61K31/59; C07C401/00; C07F7/18; (IPC1-7): C07C401/00; A61P15/00; A61P29/00; A61P35/00; A61P37/06; A61K31/593; C07F7/18
Attorney, Agent or Firm:
Chika Takagi (1 person outside)