Title:
【発明の名称】2-位に置換基を有する19-ノル-ビタミンD3 化合物
Document Type and Number:
Japanese Patent JP2898882
Kind Code:
B2
Abstract:
The 2 alpha and 2 beta -hydroxy as well as the 2 alpha (3'-hydroxypropoxy)- and 2 beta (3'-hydroxypropoxy)- and 2 alpha (benzyloxy)- analogs of 19-nor-1 alpha ,25-dihydroxyvitamin D3 are disclosed. The two 2-hydroxy analogs showed in vivo calcium transport with little or no bone calcium mobilization; the 2 beta -more than the 2 alpha - analog. Both analogs induced differentiation of malignant cells. The two analogs thus show promise in the treatment of osteoporosis. The 2 alpha -hydroxypropoxy analog showed a selective activity profile, combining high potency in inducing differentiation of malignant cells with very low or no bone calcification activity, a possible use in the treatment of malignancies.
Inventors:
HEKUTAA EFU DERUUKA
KATO ERU PERUMAN
RAFUAARU AARU SHISHINSUKII
KATO ERU PERUMAN
RAFUAARU AARU SHISHINSUKII
Application Number:
JP8919594A
Publication Date:
June 02, 1999
Filing Date:
April 05, 1994
Export Citation:
Assignee:
UISUKONSHIN ARAMUNI RISAACHI FUAUNDEESHON
International Classes:
A61K31/59; A61P3/02; A61P3/14; A61P19/10; A61P35/00; A61P43/00; C07C401/00; (IPC1-7): C07C401/00; A61K31/59
Attorney, Agent or Firm:
Takao Kawasaki (1 outside)