Title:
【発明の名称】抗ウイルス剤としての2’,3’―ジデオキシ―4’―チオリボヌクレオシド
Document Type and Number:
Japanese Patent JPH05508152
Kind Code:
A
Abstract:
2'3'-dideoxy-4'-thioribonucleosides useful as antiviral agents in the treatment and prevention of AIDS are disclosed. In accordance with one aspect of the invention there are provided compounds of the formula where X=H, N3 or F, and B is a member selected from the group consisting of pyrimidine, 5-azapyrimidine, 6-azapyrimidine, 3-deazapyrimidine, purine, 3-deazapurine, 7-deazapurine, 8-azapurine, and 2-azapurine bases. The intermediate 1-O-acetyl-5-O-t-butyldiphenylsilyl-4-thio-2,3-dideoxyribofuranose useful in the production of certain of the 2',3'-dideoxy-4'-thioribonucleosides is also disclosed.
Inventors:
Montgomery, John, A.
Sequlist, John, A., The Third
Sequlist, John, A., The Third
Application Number:
JP50884491A
Publication Date:
November 18, 1993
Filing Date:
April 19, 1991
Export Citation:
Assignee:
Southern Research Institute
International Classes:
A61K31/505; A61K31/52; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K31/7135; A61P31/12; C07D409/04; C07D473/00; C07D473/02; C07H19/04; C07H19/06; C07H19/16; C07H23/00; (IPC1-7): C07H19/06; A61K31/505; A61K31/52; A61K31/70; C07D409/04; C07D473/02; C07H19/16; C07H23/00
Attorney, Agent or Firm:
Hajime Maejima