Title:
【発明の名称】選択的ドーパミンD3リガンドとしての2-アミノインダン類
Document Type and Number:
Japanese Patent JP3342491
Kind Code:
B2
Abstract:
PCT No. PCT/US94/08046 Sec. 371 Date May 14, 1996 Sec. 102(e) Date May 14, 1996 PCT Filed Jul. 21, 1994 PCT Pub. No. WO95/04713 PCT Pub. Date Feb. 16, 1995Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of Formula I: wherein R1 and R2 are independently chosen from hydrogen, C1-C8 alkyl, OCH3, OH, OSO2CF3, OSO2CH3, SOR5, CO2R5, CONH2, CONR5R6, COR5, CN, SO2NH2, SO2NR5R6, SO2R5, -OCO-(C1-C6 alkyl), -NCO-(C1-C6 alkyl), -CH2O-(C1-C6 alkyl), -CH2OH, -CO-Aryl, -NHSO2-Aryl, -NHSO2-(C1-C6 alkyl), phthalimide, thiophenyl, pyrrol, pyrrolinyl, oxazolyl, or R1 and R2 together form -O(CH2)1-2O- or -(CH2)3-6- (except that only one of R1 and R2 can be hydrogen or OH in any such compound); R3 and R4 are independently chosen from C2-C4 alkenyl, C3-C8 alkynyl, C3-C8 cycloalkyl, -(CH2)p- thienyl (where p is 1-4), or C1-C8 alkyl (except where R1 or R2 are hydrogen or OH or where both R1 and R2 are OCH3 or a C1-C8 alkyl); R5 is hydrogen, C1-C8 alkyl, C2-C4 alkenyl, C3-C8 cycloalkyl; and R6 is C1-C8 alkyl, C2-C4 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, or Aryl.
Inventors:
Hardsmars Benson, Susan Earl
Andelson, Bengt El
Sonneson, Kras Ar
Lin, Chiu-Hong
Waters, El Nikolaus
Svenson, Cheer Are E
Carlson, P.A.
Hanson, Lars Olobe
Suchernlov, Nils Peter
Andelson, Bengt El
Sonneson, Kras Ar
Lin, Chiu-Hong
Waters, El Nikolaus
Svenson, Cheer Are E
Carlson, P.A.
Hanson, Lars Olobe
Suchernlov, Nils Peter
Application Number:
JP50642195A
Publication Date:
November 11, 2002
Filing Date:
July 21, 1994
Export Citation:
Assignee:
PHARMACIA&UPJOHN COMPANY
International Classes:
A61K31/135; A61K31/335; A61K31/357; A61K31/36; A61K31/40; A61K31/42; A61K31/421; A61P25/00; A61P25/18; A61P25/20; A61P25/28; A61P25/30; A61P43/00; C07C211/42; C07C215/42; C07C217/52; C07C217/74; C07C219/26; C07C223/04; C07C225/20; C07C225/22; C07C229/50; C07C233/43; C07C233/44; C07C237/30; C07C237/48; C07C255/54; C07C255/58; C07C309/56; C07C309/65; C07C309/66; C07C309/73; C07C309/76; C07C311/08; C07D295/08; C07C311/21; C07C311/37; C07C311/39; C07C317/32; C07C317/36; C07C323/30; C07C323/36; C07D207/325; C07D209/48; C07D263/32; C07D295/096; C07D295/12; C07D295/135; C07D317/58; C07D317/70; C07D319/14; C07D319/18; C07D333/20; C07D207/32; (IPC1-7): C07C211/42; A61K31/135; A61K31/335; A61K31/36; A61K31/40; A61K31/42; A61P25/00; A61P25/18; A61P25/20; A61P25/28; A61P25/30; A61P43/00; C07C217/74; C07C223/04; C07C225/22; C07C229/50; C07C233/43; C07C237/30; C07C255/58; C07C309/56; C07C309/76; C07C311/08; C07C311/21; C07C311/37; C07C317/32; C07C323/30; C07C323/36; C07D207/325; C07D263/32; C07D295/08; C07D295/12; C07D317/58; C07D319/18
Domestic Patent References:
| JP54154531A | ||||
| JP5262701A | ||||
| JP4626487B1 | ||||
| JP458418B1 | ||||
| JP4502620A |
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)