Title:
【発明の名称】2 ́-デオキシ-2 ́-フルオロコホルマイシンとその立体異性体
Document Type and Number:
Japanese Patent JP3030087
Kind Code:
B2
Abstract:
2'-Deoxy-2'-fluorocoformycin and 2'-deoxy-8-epi-2'-fluorocoformycin have now been synthesized by a multistage reaction via 3,5-di-O-benzoyl-2-deoxy-2-fluoro- alpha - and - beta -D-ribofuranosyl bromide. Also 2'-deoxy-2'-epi-2'-fluorocoformycin and 2'-deoxy- 8,2'-diepi-2'-fluorocoformycin have been synthesized from 3,5-di-O-benzoyl-2-deoxy-2-fluoro- alpha -D-arabinofuranosyl bromide by a multistage reaction. These four 2'-fluorocoformycin derivatives are novel compounds and have a potent enzyme inhibiting activity against adenosine deaminase. In particular, they are useful for treating acute lymphocytic leukemia in virtue of the above activity. Other novel compounds also obtained include various intermediates useful for the synthesis of the above derivatives.
Inventors:
Tomio Takeuchi
Sumio Umezawa
Osamu Tsuchiya
Yoshiaki Takahashi
Sumio Umezawa
Osamu Tsuchiya
Yoshiaki Takahashi
Application Number:
JP50914893A
Publication Date:
April 10, 2000
Filing Date:
May 21, 1992
Export Citation:
Assignee:
Foundation for Microbial Chemistry
International Classes:
C07H5/02; C07H5/06; C07H11/00; C07H19/04; C07H19/052; C07H19/23; F01K23/10; A61K31/7056; A61P31/04; A61P35/00; A61P43/00; (IPC1-7): C07H19/23
Attorney, Agent or Firm:
Shigeru Yagita (2 outside)