Title:
【発明の名称】葉酸類縁体のアミン誘導体
Document Type and Number:
Japanese Patent JP2564586
Kind Code:
B2
Abstract:
Novel therapeutic antibody conjugates comprising amine derivatives of folic acid analogs covalently attached via a reactive amine group to an oxidized carbohydrate moiety of an antibody or antibody fragment are disclosed. The conjugates retain substantially the same immunorespecificity and immunoreactivity of the unconjugated antibody molecule. The immunospecificity and immunoreactivity of the antibody conjugates permits targeted delivery of the attached therapeutically effective amine derivative of folic acid analogs in vivo. The conjugates are therapeutically effective against a variety of neoplastic and non-neoplastic cellular disorders when administered in vivo. Methods for synthesizing the amine derivatives of folic acid analogs, methods for preparing the antibody conjugates, and methods for use of the conjugates in vivo are also disclosed.
Inventors:
KUURIN DANIERU JEI
RADOKURIFU ROBAATO DEII
ROPESU ANTONII DOWAITO
ROTSUDOERU JON DEII
RADOKURIFU ROBAATO DEII
ROPESU ANTONII DOWAITO
ROTSUDOERU JON DEII
Application Number:
JP50291587A
Publication Date:
December 18, 1996
Filing Date:
May 01, 1987
Export Citation:
Assignee:
SAITOJEN CORP
International Classes:
A61K39/00; A61K39/395; A61K47/48; C07D471/00; C07D471/04; C07D239/95; C07D475/00; C07D475/02; C07D475/04; C07D475/08; G01N33/531; G01N33/532; (IPC1-7): C07D475/08; C07D239/95; C07D471/04; C07D475/02; C07D475/04
Attorney, Agent or Firm:
Yusuke Hiraki