Title:
【発明の名称】抗癌剤としてのアントラセン誘導体
Document Type and Number:
Japanese Patent JP2003516964
Kind Code:
A
Abstract:
Use of compound of Formula (I): at least one of R1, R2, R5 and R6 is a group -AB and the others are independently selected from hydrogen, hydroxy, alkoxy or acyloxy, a group -AB a group -amino-(R7)nX-Y wherein R7 is a divalent organic radical and n is 0 or 1; R3 and R4are independently oxo, hydroxy or hydrogen; the or each A is independently a spacer group of formula -amino-(R7)n-X- which is bonded to the anthracene ring via the amino group nitrogen and to B via -X-, X is independently selected from O, NH and C(O); B is an amino acid residue or a peptide group or isostere thereof and Y is hydrogen or a capping group, or a physiologically acceptable derivative of such compound for the manufacture of a medicament for the treatment of cancers or microbial infections having cells exhibiting topoisomerase I activity characterised in that the group -amino-(R7)n-X- incorporates an optionally substituted heterocyclic ring directly attached to the anthroquinone ring through an amino nitrogen in the heterocycclic ring, or an optionally substituted heterocyclic or carbocyclic ring that is spaced from the anthraquinone ring by no more than an amino nitrogen and up to four carbon atoms.
More Like This:
Inventors:
Mincher, david john
Turnbal, Agnes
Kay, Graem Gillies
Turnbal, Agnes
Kay, Graem Gillies
Application Number:
JP2001544680A
Publication Date:
May 20, 2003
Filing Date:
December 15, 2000
Export Citation:
Assignee:
BTG International Limited
International Classes:
C07D295/10; A61K31/136; A61K31/197; A61K31/198; A61K31/401; A61K31/402; A61K31/451; A61K31/495; A61K31/551; A61K38/00; A61K47/48; A61P31/04; A61P31/12; A61P31/18; A61P33/00; A61P33/02; A61P33/06; A61P35/00; C07C221/00; C07C225/26; C07C225/34; C07C237/14; C07C237/20; C07C237/22; C07C271/22; C07D207/08; C07D207/16; C07D211/26; C07D211/46; C07D243/08; C07D295/116; C07D295/12; C07D295/13; C07D295/18; C07D295/185; (IPC1-7): C07C225/34; A61K31/136; A61K31/197; A61K31/198; A61K31/401; A61K31/402; A61K31/451; A61K31/495; A61K31/551; A61K38/00; A61P31/04; A61P31/12; A61P31/18; A61P33/00; A61P33/02; A61P33/06; A61P35/00; C07C221/00; C07C237/14; C07C271/22; C07D207/08; C07D207/16; C07D211/26; C07D211/46; C07D295/10; C07D295/12; C07D295/18
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)