Title:
【発明の名称】芳香族ステロイド5‐α‐レダクターゼ抑制剤
Document Type and Number:
Japanese Patent JP2675418
Kind Code:
B2
Abstract:
Compounds of formula (I) in which X<1>, X<2> and X<3> are hydrogen, halogen, CF3, C1-6alkyl, OH, C1-6alkoxy, CN, NO2, N(R<1>)2, CHO or CO2R<1>; A is O or S, n is 0 or 1, R<1> is H or C1-8alkyl and R<3> is alpha -H, alpha -OH, or alpha -acetoxy and beta =WCOR<4>, beta -alkOR<8>; or =CHWCOR<4> or =CHWOR<8>; furanyl or alpha -H and beta -NHCOR<9>, beta -cyano or beta -tetrazolyl; or keto; processes for their preparation, intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of steroid 5- alpha -reductase activity.
Inventors:
Holt, Dennis Alan
Levy, Mark Alan
Brian Walter, Metcalf
Levy, Mark Alan
Brian Walter, Metcalf
Application Number:
JP50639189A
Publication Date:
November 12, 1997
Filing Date:
May 23, 1989
Export Citation:
Assignee:
SmithKline Beckman Corporation
International Classes:
A61K31/58; A61P5/00; C07J1/00; C07J3/00; C07J7/00; C07J9/00; C07J13/00; A61K31/565; C07J21/00; C07J31/00; C07J41/00; C07J43/00; C07J71/00; (IPC1-7): C07J1/00; A61K31/565; A61K31/58; C07J31/00; C07J41/00; C07J43/00; C07J71/00
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)