Title:
【発明の名称】喘息及び関連疾患を含むアトピー性アレルギーを治療するための標的としての喘息関連因子
Document Type and Number:
Japanese Patent JP2002505095
Kind Code:
A
Abstract:
A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein.
Inventors:
Holloid, Kenneth, Jay.
Levit, Roy, Sea.
Malloy, W., Lee
Lower Head, Jamira
MacLaine, Mike
Nikoladis, Nicholas, C.
Tzu, Yuhon
Don, cue
Levit, Roy, Sea.
Malloy, W., Lee
Lower Head, Jamira
MacLaine, Mike
Nikoladis, Nicholas, C.
Tzu, Yuhon
Don, cue
Application Number:
JP2000534221A
Publication Date:
February 19, 2002
Filing Date:
March 03, 1999
Export Citation:
Assignee:
Magainin Pharmaceuticals, Inc.
International Classes:
G01N33/53; A61K31/7088; A61K38/00; A61K38/20; A61K39/395; A61K45/00; A61P1/00; A61P11/00; A61P11/06; A61P37/08; A61P43/00; C07H21/04; C07K14/705; C12N15/09; C12N15/12; C12P21/08; G01N33/68; (IPC1-7): C12N15/09; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61P1/00; A61P11/00; A61P11/06; A61P37/08; A61P43/00; C07H21/04; C12P21/08; G01N33/53
Attorney, Agent or Firm:
Yuichi Yamada (1 person outside)