Title:
【発明の名称】不斉閉環メタセシス反応
Document Type and Number:
Japanese Patent JP2002504487
Kind Code:
A
Abstract:
A composition and method for the catalytic conversion of a racemic mixture of dienes to a cyclic olefin by a ring-closing metathesis (RCM) reaction are disclosed. The composition, a transition metal complex with an M=C reaction site, contains a bidentate dialkoxide of at least 80% optical purity. Because the M=C reaction site is of a sufficient shape specificity, conferred in part by the dialkoxide of sufficient rigidity and an M=N-R<1> site, reacting the composition with a mixture of two enantiomeric dienes results in an olefin metathesis product that has at least a 50% enantiomeric excess of one enantiomer in the mixture. A method is also provided for reacting a composition with a racemic diene mixture to generate a metathesis product that has an enantiomeric excess of at least 50%.
Inventors:
Schrock, Richard Earl
Alexander, John Bee
Alexander, John Bee
Application Number:
JP2000532421A
Publication Date:
February 12, 2002
Filing Date:
February 19, 1999
Export Citation:
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
International Classes:
B01J31/12; B01J31/18; B01J31/22; B01J31/34; C07B61/00; C07C6/04; C07F7/18; C07F11/00; (IPC1-7): C07F11/00; B01J31/12; C07C6/04
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)