Title:
【発明の名称】治療薬としてのバルビツール酸類似体
Document Type and Number:
Japanese Patent JP2003535123
Kind Code:
A
Abstract:
This invention pertains to active barbituric acid analogs which inhibit HIF-1 activity (e.g., the interaction between HIF-1$g(a) and p300) and thereby inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HIF-1 activity, and to inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer.
Inventors:
De Verin, Jackie Wye
Romero-Martin, Maria-Rosario
Finn, Paul W
Thayes, Lee Gee
Lowe, Norman M
Billyington, David Sea
Riley, steven
Battacharya, Ginger
Romero-Martin, Maria-Rosario
Finn, Paul W
Thayes, Lee Gee
Lowe, Norman M
Billyington, David Sea
Riley, steven
Battacharya, Ginger
Application Number:
JP2002501414A
Publication Date:
November 25, 2003
Filing Date:
June 05, 2001
Export Citation:
Assignee:
Nobu Pharma Sochieta Per Azioni
International Classes:
A61K31/506; A61K31/513; A61K31/515; A61K31/519; A61K31/522; A61K31/525; A61P9/00; A61P35/00; A61P43/00; C07D239/62; C07D239/66; C07D403/06; C07D405/06; C07D409/06; C07D409/14; C07D473/06; C07D473/08; C07D475/14; C07D487/04; (IPC1-7): A61K31/506; A61K31/513; A61K31/515; A61K31/519; A61K31/522; A61K31/525; A61P9/00; A61P35/00; A61P43/00; C07D239/62; C07D239/66; C07D405/06; C07D409/06; C07D409/14; C07D473/08; C07D475/14; C07D487/04
Domestic Patent References:
| JPH1048824A | 1998-02-20 | |||
| JPH0196628A | 1989-04-14 | |||
| JPS4222775B1 |
Foreign References:
| WO2000013708A1 | 2000-03-16 | |||
| SU1129202A1 | 1984-12-15 | |||
| PL77134B1 | 1975-02-28 | |||
| US3819595A | 1974-06-25 | |||
| DE2042663A1 | 1972-03-02 | |||
| US3331687A | 1967-07-18 |
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)