Title:
【発明の名称】免疫応答を阻害するCD4-誘導ペプチド
Document Type and Number:
Japanese Patent JPH11510792
Kind Code:
A
Abstract:
The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4+ T cell immune responses by identifying compounds that block the interaction of CD4 and MHC, class II, gene products and a method of treatment which comprises administering such an identified compound. The compounds that inhibit undesired human CD4+ T cell immune responses can be used to treat disease such as multiple sclerosis and to prevent graft rejection and graft versus host disease. More specifically, the application concerns compounds having molecular weights between about 1400 and 400 that mimic three portions of the human CD4 lymphocyte cell surface antigen. The portions are residues 29-35, the C-C' loop of the D1 domain; residues 317-323, the C-C' loop of the D4 domain; and residues 346-353, the CDR3 or FG ridge of the D4 domain of the CD4 molecule. Specific examples of such compounds include cyclic peptides and peptidomimetic.
Inventors:
Corn gold, robert
Hubert Bur
Hubert Bur
Application Number:
JP50461397A
Publication Date:
September 21, 1999
Filing Date:
June 28, 1996
Export Citation:
Assignee:
Thomas Jefferson University
International Classes:
A61K31/00; A61K31/395; A61K38/00; A61P25/00; A61P37/00; C07D255/02; A61P37/06; C07K7/06; C07K14/73; (IPC1-7): C07K7/06; A61K31/00; A61K31/395; A61K38/00; C07D255/02
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)