Title:
【発明の名称】Candidaalbicans(カンジダアルビカンス)由来のホスホメバロネートキナーゼ(PMK)遺伝子(ERG8)
Document Type and Number:
Japanese Patent JP2003507060
Kind Code:
A
Abstract:
This invention relates to polynucleotides, polypeptides encoded by these polynucleotides, to the production of such polynucleotides and polypeptides, and to the uses of such polynucleotides and polypeptides. More specifically, the invention relates to the phosphomevalonate kinase (PMK) gene (ERG8 gene) from Candida Albicans (C. albicans), to methods for its expression yielding phosphomevalonate kinase protein, to hybrid organisms for use in such expression methods, to methods for purification of the protein, to methods and tools for diagnosing C. albicans infection and to assays for identifying inhibitors of the enzyme which inhibitors have potential as anti-fungal agents.
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Inventors:
Rosamond, John David Charles
Schnell, Norbert Friedman
Schnell, Norbert Friedman
Application Number:
JP2001518847A
Publication Date:
February 25, 2003
Filing Date:
August 15, 2000
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
G01N33/53; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12N15/09; C12P21/08; C12Q1/68; G01N33/566; C12R1/725; (IPC1-7): C12N15/09; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12Q1/68; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)