【発明の名称】或る種の4-アミノメチル-2-置換イミダゾール誘導体および2-アミノメチル-4-置換イミダゾール誘導体;新規な種類のドーパミンリセプタ亜型特異性リガンド

Title:

Document Type and Number:

Japanese Patent JP2941950

Kind Code:

B2

Abstract:

Disclosed are compounds of formula (III), wherein R1 represents optionally substituted aryl, heteroaryl, arylalkyl, or cycloalkyl groups; X, Z, and Y are optionally substituted nitrogen or carbon atoms; R3 and R4 are organic or inorganic substituents which may together form ring structures; m is zero, one or two; and R5 and R6 are organic or inorganic substituents; and the pharmaceutically acceptable addition salts thereof, which compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.

More Like This:

JPS61197530	METHOD OF RACEMIZATION
JPH0757759	INDUSTRIAL APPLICABILITY: Fluorine-containing renin inhibitor
JP3263241	BENZENE DERIVATIVE USEFUL FOR TREATMENT OF ISCHEMIC DISEASE

Inventors:

SAAKAUFU ANDORYUU
HOOASU REIMANDO EFU
YUAN JUN
PIITAASUN JON EMU

Application Number:

JP51707495A

Publication Date:

August 30, 1999

Filing Date:

November 22, 1995

Export Citation:

Click for automatic bibliography generation Help

Assignee:

NYUUROGEN CORP

International Classes:

C07D233/64; A61K31/00; A61K31/415; A61K31/4164; A61K31/4178; A61K31/4427; A61K31/445; A61K31/4465; A61K31/4523; A61K31/505; A61K31/506; A61P25/00; A61P25/16; A61P25/18; A61P25/24; A61P25/26; A61P43/00; C07D233/54; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D487/08; (IPC1-7): C07D233/64; C07D233/64; C07D401/06; C07D401/14; C07D403/12; C07D487/08

Domestic Patent References:

JP6504054A

Attorney, Agent or Firm:

Hidekazu Miyoshi (1 outside)

Previous Patent: ステンレス鋼アルカリ処理

Next Patent: 新規なタキソイド、その製造及びそれを含有する製薬学的組成物