【発明の名称】置換アクリロイルジスタマイシン誘導体、タキサン類及び/又は代謝拮抗剤を含む腫瘍に対する併用療法

Title:

【発明の名称】置換アクリロイルジスタマイシン誘導体、タキサン類及び/又は代謝拮抗剤を含む腫瘍に対する併用療法

Document Type and Number:

Japanese Patent JP2003535874

Kind Code:

A

Abstract:

The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-bromo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and antimicrotubule agents. Also provided is the use of the said combination in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogcncsis.

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Inventors:

Gieroni, Maria Cristina Rosa
Kotsui, Paolo
Berea, Italo

Application Number:

JP2002503104A

Publication Date:

December 02, 2003

Filing Date:

June 20, 2001

Export Citation:

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Assignee:

Falmatia Italy Esset Pear

International Classes:

A61K31/337; A61K31/40; A61K31/4025; A61K31/4155; A61K31/4178; A61K31/475; A61K31/505; A61K31/513; A61K31/519; A61K31/565; A61K31/7064; A61K31/7068; C07D305/14; A61K45/06; A61P35/00; C07D207/456; C07D519/04; (IPC1-7): A61K31/337; A61K31/4025; A61K31/4155; A61K31/4178; A61K31/475; A61K31/513; A61K31/519; A61K31/7068; A61P35/00

Attorney, Agent or Firm:

Yoshio Kawaguchi (4 outside)

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