Title:
【発明の名称】アルツハイマー病の死前の診断、インビボ画像化、およびアミロイド沈着の予防のための化合物
Document Type and Number:
Japanese Patent JP2001522829
Kind Code:
A
Abstract:
Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing Chrysamine G and derivatives thereof and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.
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Inventors:
Crank William E.
Pete glue Jay W.
Matisse Chester A. Jr.
Pete glue Jay W.
Matisse Chester A. Jr.
Application Number:
JP2000520408A
Publication Date:
November 20, 2001
Filing Date:
November 06, 1998
Export Citation:
Assignee:
University of Pittsburgh
International Classes:
A61K31/603; A61K31/665; A61K49/00; A61K49/04; A61K49/06; A61P25/00; C07C65/19; C07C229/64; C07C233/87; C07C235/56; C07C243/22; C07C245/08; C07C245/10; C07C251/24; G01N33/53; C07C251/86; C07C309/46; C07D213/80; C07D257/04; C07D261/20; C07D271/10; C07F7/22; C09B35/10; G01N33/566; G01N33/68; (IPC1-7): C07C229/64; A61K49/00; A61P25/00; C07C235/56; C07C243/22; C07C245/08; C07C251/24; C07C251/86; C07C309/46; C07D257/04; C07D271/10; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Shimizu Hatsushi (1 person outside)