Title:
【発明の名称】セロトニン作動薬としてのシクロアルキル-置換アリール-ピペラジン、ピペリジンおよびテトラヒドロピリジン
Document Type and Number:
Japanese Patent JP2002518382
Kind Code:
A
Abstract:
This invention relates to compounds which have activity as 5-HT1A agonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer. Useful compounds are those of formula (I) where: X is selected from the group consisting of (1), (2), (3); n is selected from the integers 1 through 5; R<1> is optionally substituted C6-C10-aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; R<2> is selected from the group consisting of H and C1-C6 alkyl; R<3> is selected from the group consisting of H, COR<5>, COOR<5>, and CONR<5>R<6>; R<4>, R<5> and R<6> are as defined hereinabove; or an optical isomer; or a pharmaceutically acceptable salt thereof.
Inventors:
Wayne Everett Childers
Michael gerrard kelly
Ibet Latco Palmer
Edward James Podley
Michael gerrard kelly
Ibet Latco Palmer
Edward James Podley
Application Number:
JP2000554713A
Publication Date:
June 25, 2002
Filing Date:
June 14, 1999
Export Citation:
Assignee:
American Home Products Corporation
International Classes:
C07D295/12; A61K31/4418; A61K31/445; A61K31/495; A61K31/496; A61P1/08; A61P13/08; A61P25/22; A61P25/24; A61P25/28; A61P35/00; A61P43/00; C07D209/08; C07D211/22; C07D211/70; C07D295/13; C07D319/18; (IPC1-7): C07D209/08; A61K31/4418; A61K31/445; A61K31/495; A61K31/496; A61P1/08; A61P13/08; A61P25/22; A61P25/24; A61P25/28; A61P35/00; A61P43/00; C07D211/22; C07D211/70; C07D295/12; C07D319/18
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)