Title:
【発明の名称】サイトカイン誘導タンパク質、TSG-14、そのためのDNAコード化およびその使用
Document Type and Number:
Japanese Patent JPH06506195
Kind Code:
A
Abstract:
Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a polypeptide molecule, termed TSG-14, in connective tissue cells. The TSG-14 polypeptide and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the polypeptide and the DNA are provided. Antibodies specific for the TSG-14 polypeptide are disclosed, as is a method for detecting the presence of TSG-14 polypeptide in a biological sample, using the antibody or another molecule capable of binding to TSG-14 such as hyaluronic acid. A method for detecting the presence of nucleic acid encoding a normal or mutant TSG-14 polypeptide, a method for measuring induction of expression of TSG-14 in a cell using either nucleic acid hybridization or immunoassay, a method for identifying a compound capable of inducing the expression of TSG-14 in a cell, and a method for measuring the ability of a cell to respond to TNF are also provided.
Inventors:
Lee, Taeho
Lee, Jean W
Birsec, Jean
Lee, Jean W
Birsec, Jean
Application Number:
JP50457292A
Publication Date:
July 14, 1994
Filing Date:
January 14, 1992
Export Citation:
Assignee:
New York University
International Classes:
A61K39/395; C07K14/00; C07K14/47; C07K14/52; C07K14/54; C07K14/545; C07K14/78; C07K16/00; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12Q1/68; G01N33/53; A61K38/00; C12R1/19; (IPC1-7): C07K13/00; A61K39/395; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Eiko Funahashi