Title:
【発明の名称】ヒトセリンプロテアーゼC-EをコードするDNA
Document Type and Number:
Japanese Patent JP2003508044
Kind Code:
A
Abstract:
Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease C-E mRNA is expressed in pancreas, placenta, prostate, small intestine, stomach, spleen, fibroblasts and epidermis, as well as in certain regions of the brain i.e., cerebellum, cerebral cortex, pituitary and hippocampus. Enzymatically active protease C-E, as produced using the methodologies described herein, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.
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Inventors:
Darrow, Andrew
Chi, chien sen
Andrei-Gordon, Patricia
Chi, chien sen
Andrei-Gordon, Patricia
Application Number:
JP2001520836A
Publication Date:
March 04, 2003
Filing Date:
August 14, 2000
Export Citation:
Assignee:
Ortho-McNeill Pharmacy Incorporated
International Classes:
A61K8/00; A61K8/66; A61K8/72; A61K31/7125; A61K35/76; A61K38/48; A61K45/00; A61K48/00; A61P1/00; A61P1/18; A61P13/08; A61P15/00; A61P17/00; A61P17/16; A61P25/00; A61P25/28; A61P43/00; A61Q5/02; C07K16/40; C11D3/386; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/64; C12N15/09; C12N15/57; G01N33/50; C12P21/08; C12Q1/37; G01N33/15; A61K38/00; (IPC1-7): C12N15/09; A61K7/00; A61K7/075; A61K31/7125; A61K35/76; A61K38/48; A61K45/00; A61K48/00; A61P1/00; A61P1/18; A61P13/08; A61P15/00; A61P17/00; A61P17/16; A61P25/00; A61P25/28; A61P43/00; C07K16/40; C11D3/386; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/64; C12Q1/37; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)