【発明の名称】ジピリドキシルホスフエ―トNMRI造影剤

Title:

【発明の名称】ジピリドキシルホスフエ―トNMRI造影剤

Document Type and Number:

Japanese Patent JP2512524

Kind Code:

B2

Abstract:

N,N min -bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N min -diacetic acids, N,N min -bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine N,N min -diacetic acids, and N,N min -bis-(pyridoxal-5-phosphate)-1,2-arylenediamine-N,N min -diacetic acids, the corresponding monophosphate compounds and monoacetic acid compounds, and their salts and esters form stable, highly soluble chelates with paramagnetic metal ions, and are highly effective NMRI contrast agents. Preferred contrast agents are paramagnetic ion chelates of N,N min -bis-(pyridoxal-5-phosphate)ethylene diamine-N,N min -diacetic acid, N,N min -bis-(pyridoxal-5-phosphate)trans-1,2-cyclohexylenediamine-N,N min -diac etic acid, N,N min -bis-(pyridoxal-5-phosphate)trans-1,2-arylenediamine-N,N min -diacetic acid, and the soluble calcium salts thereof. Novel intermediates for forming these compounds are N,N min -bis(pyridoxal-5-phosphate)alkylenediimines, N,N min -bis(pyridoxal-5-phosphate)alkylenediamines, N,N min -bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediimines, N,N min -bis(pyridoxal-5-phosphate)-1,2-cycloalkylenediamines, N,N min -bis(pyridoxal-5-phosphate)-1,2-arylenediamines, and the corresponding monophosphate compounds.

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Inventors:

SUKOTSUTO EMU ROTSUKUREIJI
SUCHIIBUN SHII KII

Application Number:

JP10993188A

Publication Date:

July 03, 1996

Filing Date:

May 07, 1988

Export Citation:

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Assignee:

SALUTAR INC

International Classes:

A61K49/00; A61B5/055; A61B10/00; A61K49/06; C07F1/00; C07F1/08; C07F5/00; C07F9/58; C07F11/00; C07F13/00; C07F15/00; C07F15/02; C07F15/04; C07F15/06; G01R33/28; (IPC1-7): C07F9/58; A61B10/00; A61K49/00; C07F1/08; C07F5/00; C07F11/00; C07F13/00; C07F15/02; C07F15/04; C07F15/06

Attorney, Agent or Firm:

Heiyoshi Odashima

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