Title:
【発明の名称】リポソ-ム類における抗腫瘍剤類の被包
Document Type and Number:
Japanese Patent JPH07112968
Kind Code:
B2
Abstract:
Methods for encapsulating ionizable antineoplastic agents in liposomes using transmembrane potentials. Trapping efficiencies approaching 100% and rapid loading are readily achieved. Dehydration protocols which allow liposomes to be conveniently used in the administration of antineoplastic agents in a clinical setting are also provided. In accordance with other aspects of the invention, transmembrane potentials are used to reduce the rate of release of ionizable drugs from liposomes.
Inventors:
BARII MARUSERU BII
KYURISU PIITAA AARU
HOOPU MAIKERU JEI
MATSUDEN TOOMASU DEI
MAIYAA ROORENSU DEI
KYURISU PIITAA AARU
HOOPU MAIKERU JEI
MATSUDEN TOOMASU DEI
MAIYAA ROORENSU DEI
Application Number:
JP50362785A
Publication Date:
December 06, 1995
Filing Date:
August 07, 1985
Export Citation:
Assignee:
RIHOZOOMU CO INC ZA
International Classes:
A61K45/08; A61K9/00; A61K9/10; A61K9/127; A61K31/435; A61K31/505; A61K31/519; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7068; A61K45/00; A61K47/48; A61P35/00; C07D475/08; C07D519/00; C07H15/252; C07H19/09; (IPC1-7): A61K9/127; A61K45/08
Domestic Patent References:
| JPS5459314A | 1979-05-12 | |||
| JPS55100313A | 1980-07-31 |
Other References:
ＣｈｅｍｉｃａｌＡｂｓｔｒａｃｔｓ，９９（１６），１２８２５９ｃ（１９８３）
Attorney, Agent or Firm:
Akitoshi Otawa (1 outside)