Title:
【発明の名称】エンドペプチダーゼのカルボキシアルキルジペプチド阻害剤
Document Type and Number:
Japanese Patent JPH05501247
Kind Code:
A
Abstract:
Carboxyalkyl dipeptide inhibitors of endopeptidases of formula (I) or pharmaceutically acceptable salt thereof, wherein R<1> is H, alkyl, arylalkyl or aryl; R<2> is H, alkyl, alkenyl or alkynyl, wherein the alkyl portion is substituted with 0-3 substituents independently selected from the group consisting of hydroxy, alkoxy, alkoxyalkoxy, alkylthio, aryl, alkoxyalkylthio, arylalkoxy and arylalkylthio; R<3> and R<4> are independently alkyl or arylalkyl; or R<3> and R<4> together with the carbon to which they are attached form an optionally substituted 5-, 6- or 7-membered ring wherein said ring comprises 0 to 1 heteroatoms selected from the group consisting of sulfur and oxygen; R<5> is H, alkyl, alkoxyalkyl, alkylthioalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, arylalkoxyalkyl or arylalkylthioalkyl; R<6> is hydroxy, alkoxy, or R<5>; R<7> is hydroxy, alkoxy, aryloxy, arylalkoxy, amino, alkylamino or dialkylamino; m is 0 or 1; and n is 0, 1, 2, or 3, use of the compounds, alone or in combination with an ACE inhibitor or an ANF, in the treatment of cardiovascular disorders such as hypertension, congestive heart failure, edema and renal insufficiency, use of the compounds in the treatment of pain conditions, and pharmaceutical compositions containing said compounds are disclosed.
Inventors:
Martin Lang, Haslanger
Newstat, Bernard Earl
Smith, Elizabeth M
Newstat, Bernard Earl
Smith, Elizabeth M
Application Number:
JP51384690A
Publication Date:
March 11, 1993
Filing Date:
October 10, 1990
Export Citation:
Assignee:
SCHERING CORPORATION
International Classes:
A61K31/195; A61K31/215; A61K31/22; A61K31/40; A61K31/403; A61K31/404; A61K31/47; A61K31/473; A61K31/55; A61K38/04; A61K38/22; A61K38/55; A61P9/00; A61P9/12; A61P13/02; A61P15/00; C07C237/12; C07C237/22; C07C323/12; C07C323/41; C07D207/16; C07D209/18; C07D221/04; C07D495/10; C07K1/113; C07K5/06; C07K5/065; A61K38/00; (IPC1-7): A61K31/195; A61K31/215; A61K31/22; A61K31/40; A61K31/47; A61K31/55; A61K37/24; A61K37/64; C07C237/12; C07C237/22; C07C323/12; C07C323/41; C07D207/16; C07D209/18; C07D221/04; C07D495/10; C07K5/06
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)