Title:
【発明の名称】平滑筋細胞増殖阻害薬としてのエステル化ポリアニオン性シクロデキストリン
Document Type and Number:
Japanese Patent JPH10501575
Kind Code:
A
Abstract:
This invention relates esterified polysulfated cyclodextrins, their use in treating diseases and conditions which are characterized by excessive smooth muscle cell (SMC) proliferation such as restenosis and a pharmaceutical composition thereof. The compounds useful in this invention are represented by Formula I: I where: M is a pharmaceutically acceptable cation; R is selected from the group consisting of C1-C12 lower alkyl, C3-C12 cycloalkyl, and aryl optionally substituted with 1-3 substituents independently selected from halogen, C1-C12 lower alkyl or C1-C12 alkoxy; and n is an integer from 6-8, representing alpha -cyclodextrin (n=6), beta -cyclodextrin (n=7), and gamma -cyclodextrin (n=8).
Inventors:
Saul, Richard Michael
Application Number:
JP50214795A
Publication Date:
February 10, 1998
Filing Date:
May 03, 1995
Export Citation:
Assignee:
American Home Products Corporation
International Classes:
A61K31/715; A61K31/724; A61K31/737; A61P43/00; C08B37/16; (IPC1-7): C08B37/16; A61K31/72
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)