Title:
【発明の名称】ファルネシル―タンパク質転移酵素の阻害剤
Document Type and Number:
Japanese Patent JP2000507955
Kind Code:
A
Abstract:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
Inventors:
Dyne Moore, Christopher
Anthony, Neville
Stellsker, The Rerald Y
Robert Gomez
Anthony, Neville
Stellsker, The Rerald Y
Robert Gomez
Application Number:
JP53563497A
Publication Date:
June 27, 2000
Filing Date:
April 01, 1997
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/00; A61K31/415; A61K31/4164; A61K31/44; A61K31/4409; A61P13/00; A61P13/12; A61P27/00; A61P27/02; A61P31/00; A61P31/10; A61P31/12; A61P35/00; C07D213/57; C07D233/54; C07D233/56; C07D233/61; C07D233/70; C07D401/14; C07D403/10; C07D403/14; C07D409/10; C07D409/14; C07D413/06; C07D417/06; C07D417/14; (IPC1-7): C07D213/57; A61K31/4164; A61K31/4409; A61P13/12; A61P27/02; A61P31/10; A61P31/12; A61P35/00; C07D233/54; C07D233/61
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)