Title:
【発明の名称】ファルネシル-タンパク質転移酵素の阻害剤
Document Type and Number:
Japanese Patent JPH11510388
Kind Code:
A
Abstract:
The present invention is directed to non-peptide compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention also relates to the process for the preparation of a compound of this invention by cultivating a culture of Phoma sp. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
Inventors:
Cascales, Carmen
Russell Bee, Lingham
Peraes, Fernando
Police, Jiyoung Day
Keith Sea, Silberman
Singa, Cie Bee
Zinc, Deborah El
Russell Bee, Lingham
Peraes, Fernando
Police, Jiyoung Day
Keith Sea, Silberman
Singa, Cie Bee
Zinc, Deborah El
Application Number:
JP50768897A
Publication Date:
September 14, 1999
Filing Date:
July 22, 1996
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
C12N15/00; A61K31/00; A61K31/35; A61K31/352; A61P35/00; C07D493/04; C12N1/14; C12N9/99; C12N15/01; C12P17/18; C12R1/645; (IPC1-7): C12P17/18; A61K31/00; A61K31/35; C07D493/04; C12N1/14; C12N9/99; C12N15/01
Attorney, Agent or Firm:
Yoshio Kawaguchi (1 person outside)