Title:
【発明の名称】レチノイド様生物学的活性を有するヘテロアリール置換フェニルエテニル化合物
Document Type and Number:
Japanese Patent JP3499553
Kind Code:
B2
Abstract:
Compounds of the formula where R1, R2, R3 and R4 independently are hydrogen, lower alkyl of 1-6 carbons, halogen or lower alkoxy of 1-6 carbons; R5 and R5' independently are hydrogen or lower alkyl of 1-6 carbons; Y is oxygen or sulfur; Z is n-alkyl having 1-10 carbons, cyclo or branch-chained alkyl of 3-10 carbons, and straight chain alkenyl having 2-10 carbons, or cyclo or branched chained alkenyl of 3-10 carbons; X is thienyl, pyridyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl and oxazolyl; A is (CH2)n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR8, CONR9R10, -CH2OH, CH2OR11, CH2OCOR11, CHO, CH(OR12)2, CHOR13O, -COR7, CR7(OR12)2, or CR 7OR13O, where R7 is an alkyl, cycloalkyl or alkenyl group containing 1-5 carbons, R8 is an alkyl group of 1-10 carbons, or a cycloalkyl group of 5-10 carbons, or R8 is phenyl or lower alkylphenyl, R9 and R10 independently are hydrogen, an alkyl group of 1-10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R11 is alkyl of 1-10 carbons, phenyl or lower alkylphenyl, R12 is lower alkyl, and R13 is divalent alkyl radical of 2-5 carbons, have retinoic acid like biological activity.
Inventors:
Chandra Ratna, Roshansa A.S.
Application Number:
JP51424093A
Publication Date:
February 23, 2004
Filing Date:
February 08, 1993
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
International Classes:
C07D239/26; A61K31/34; A61K31/341; A61K31/38; A61K31/381; A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/44; A61K31/4406; A61K31/4418; A61P3/02; A61P9/10; A61P13/08; A61P15/00; A61P17/00; A61P17/04; A61P17/06; A61P17/10; A61P27/02; A61P35/00; C07D213/78; C07D213/80; C07D239/28; C07D263/32; C07D263/34; C07D277/22; C07D307/68; C07D333/16; C07D333/18; C07D333/24; C07D333/38; C07D333/40; (IPC1-7): C07D333/38; C07D333/40
Domestic Patent References:
| JP381240A | ||||
| JP63190878A | ||||
| JP5283360A |
Other References:
【文献】欧州特許436398(EP,B1)
【文献】米国特許3705153(US,A)
【文献】米国特許3705153(US,A)
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)