Title:
【発明の名称】第Xa因子の阻害剤
Document Type and Number:
Japanese Patent JP2002536432
Kind Code:
A
Abstract:
Alkenyl and alkynyl compounds as potent and highly selective inhibitors of factor Xa isolated or assembled in the prothrombinase complex and compositions containing such alkenyl and alkynyl compounds are described. Such compounds show selectivity for factor Xa over other proteases of the coagulation (e.g., thrombin, fvIIa, flXa) or the fibrinolytic cascades (e.g., plasminogen activators, plasmin). Methods for using such alkenyl and alkynyl compounds as diagnostic or therapeutic agents for prevention or treatment of a condition in a mammal characterized by undesired coagulation disorders, such as thrombosis, are also described.
Inventors:
Song, Yong Hong
Shu, Bin-Yang
Scarborough, Robert, M.
Cribbe, Lane
Zia, Shation, John
Sue tin
Ten, willie
Shu, Bin-Yang
Scarborough, Robert, M.
Cribbe, Lane
Zia, Shation, John
Sue tin
Ten, willie
Application Number:
JP2000598475A
Publication Date:
October 29, 2002
Filing Date:
February 11, 2000
Export Citation:
Assignee:
COR Therapeutics, Inc.
International Classes:
C07D295/14; A61K31/18; A61K31/192; A61K31/195; A61K31/216; A61K31/341; A61K31/40; A61K31/41; A61K31/415; A61K31/4174; A61K31/44; A61K31/4409; A61K31/472; A61K31/4725; A61K31/495; A61K31/505; A61K31/517; A61P7/00; A61P7/02; A61P7/04; A61P9/00; A61P9/10; A61P11/00; A61P31/04; A61P43/00; C07C257/18; C07C311/29; C07C311/46; C07C311/51; C07D213/56; C07D213/58; C07D213/70; C07D213/74; C07D213/75; C07D217/22; C07D231/12; C07D233/61; C07D239/42; C07D239/94; C07D257/04; C07D295/16; C07D307/54; C07D401/12; C07D521/00; (IPC1-7): C07C311/46; A61K31/18; A61K31/195; A61K31/216; A61K31/341; A61K31/415; A61K31/44; A61K31/4409; A61K31/472; A61K31/4725; A61K31/517; A61P7/00; A61P7/02; A61P7/04; A61P9/10; A61P43/00; C07C257/18; C07D213/56; C07D213/70; C07D213/75; C07D217/22; C07D231/12; C07D239/94; C07D307/54; C07D401/12
Attorney, Agent or Firm:
Yuichi Yamada (1 person outside)