Title:
【発明の名称】イオン的に架橋されたポリマーマイクロカプセル
Document Type and Number:
Japanese Patent JP3471796
Kind Code:
B2
Abstract:
A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked with multivalent ions of the opposite charge to form a gel encapsulating biological material, that is optionally further stabilized by interactions with multivalent polyions of the same charge as those used to form the gel. In the preferred embodiment, hydrolytically stable polyphosphazenes are formed of monomers having carboxylic acid side groups that are crosslinked by divalent or trivalent cations such as Ca2+ or Al3+, then stabilized with a polycation such as poly-L-lysine. A variety of different compositions can be formed from the crosslinked polymer. In a preferred embodiment, microcapsules are made by spraying an aqueous solution of polyphosphazene and material to be encapsulated into a calcium chloride solution.
Inventors:
Cohen, Samadar
Bano, Carmen
Bischer, Karin Bee.
Butterfly, Mary Bee.
Alcock, Harry Earl.
Langer, Robert S.
Bano, Carmen
Bischer, Karin Bee.
Butterfly, Mary Bee.
Alcock, Harry Earl.
Langer, Robert S.
Application Number:
JP51730491A
Publication Date:
December 02, 2003
Filing Date:
October 04, 1991
Export Citation:
Assignee:
Massachusetts Institute of Technology
The Penn State Research Foundation
The Penn State Research Foundation
International Classes:
A61K9/127; A61K9/16; A61K9/50; A61K31/70; A61K31/708; A61K31/715; A61K35/12; A61K38/00; A61K47/02; A61K47/30; A61K47/32; A61K47/34; A61K49/22; A61K51/12; B01J13/02; B01J13/10; B01J13/14; C08G79/02; C12N11/04; (IPC1-7): A61K9/50; A61K31/708; A61K31/715; A61K35/12; A61K38/00; A61K47/02; A61K47/32; A61K47/34; B01J13/02; C12N11/04
Domestic Patent References:
| JP60258121A | ||||
| JP57120518A |
Attorney, Agent or Firm:
Shusaku Yamamoto