Title:
【発明の名称】マトリックスメタロプロテイナーゼ阻害剤
Document Type and Number:
Japanese Patent JP2001511139
Kind Code:
A
Abstract:
A compound of formula (I), wherein W is -NHOH or -OH, R1 is either free or protected hydroxymethyl or mercaptomethyl or derivatives thereof, R2 is free or protected hydroxy, R3 and R4 is an organic group, R5 is hydrogen or methyl, or R4 and R5, together with the nitrogen atom to which they are attached, constitute an azaheterocyclyl group, and the solvates, hydrates and pharmaceutically acceptable salts thereof, can inhibit matrix metalloproteinases and the release of tumour necrosis factor (TNF). Processes for producing the compound, intermediates involved in the processes, and pharmaceutical compositions containing the compound are also described.
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Inventors:
Arpeggiani, Marco
Paradino, Matsusimiliano
Corrigry, Ricardo
Jabes, Daniela
Petrone, Ettore
Abrate, Franchiesca
Bitssolino, Pierre Luigi
Rombroso, Marina
Paradino, Matsusimiliano
Corrigry, Ricardo
Jabes, Daniela
Petrone, Ettore
Abrate, Franchiesca
Bitssolino, Pierre Luigi
Rombroso, Marina
Application Number:
JP53254398A
Publication Date:
August 07, 2001
Filing Date:
January 23, 1998
Export Citation:
Assignee:
Farmacia e Appzyon Esset Pear
International Classes:
A61K31/16; A61K31/165; A61K31/221; A61K31/27; A61K31/336; A61K31/351; A61K31/357; A61K31/36; A61K31/366; A61K31/381; A61K31/41; A61K31/426; A61K31/439; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4439; A61K31/4453; A61K31/4468; A61K31/47; A61K31/472; A61K31/5375; A61P19/02; A61P29/00; A61P35/00; A61P35/04; A61P37/00; A61P43/00; C07C69/34; C07C69/675; C07C259/06; C07C259/08; C07D211/58; C07D213/40; C07D213/55; C07D213/56; C07D213/65; C07D213/70; C07D213/75; C07D215/12; C07D215/38; C07D217/02; C07D217/04; C07D217/16; C07D217/22; C07D233/54; C07D237/02; C07D257/04; C07D277/20; C07D277/30; C07D277/44; C07D295/18; C07D295/185; C07D295/12; C07D303/40; C07D303/48; C07D305/12; C07D307/33; C07D309/12; C07D311/20; C07D317/30; C07D317/34; C07D317/58; C07D317/66; C07D333/34; C07D405/12; C07D417/12; C07D453/02; C07D491/04; (IPC1-7): C07C259/06; A61K31/16; A61K31/165; A61K31/221; A61K31/27; A61K31/336; A61K31/351; A61K31/357; A61K31/36; A61K31/366; A61K31/381; A61K31/41; A61K31/426; A61K31/439; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4439; A61K31/4453; A61K31/4468; A61K31/47; A61K31/472; A61K31/5375; A61P19/02; A61P29/00; A61P35/00; A61P35/04; A61P37/00; A61P43/00; C07D211/58; C07D213/55; C07D213/65; C07D213/75; C07D215/38; C07D217/04; C07D217/16; C07D217/22; C07D257/04; C07D277/44; C07D295/12; C07D295/18; C07D303/40; C07D305/12; C07D307/33; C07D309/12; C07D317/30; C07D317/34; C07D317/58; C07D333/34; C07D405/12; C07D417/12; C07D453/02
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)