Title:
【発明の名称】イミダゾジアゼピン誘導体の製造方法
Document Type and Number:
Japanese Patent JP3107762
Kind Code:
B2
Abstract:
A process for the manufacture of compounds of formula I wherein A together with the two carbon atoms denoted as alpha and beta represents one of the groups R<1> represents cyano or a group of the formula -COOR<4>, R<2> represents hydrogen, R<3> represents lower alkyl, or R<2> and R<3> together signify a di- or trimethylene group, R<4> represents lower alkyl or benzyl; and R<5>, R<6> each signify hydrogen, halogen, trifluoromethyl, lower alkoxy or nitro and the carbon atom denoted by gamma has the S-configuration when R<2> is different from hydrogen which process comprises reacting a compound of the formula wherein A, R<2> and R<3> have the significance given above and X represent a halogen atom, in the presence of a base with a compound of the formula wherein R<7> is lower alkyl or cycloalkyl and R<1> has the significance given above.
Inventors:
Mark Rogers-Evans
Paul Spur
Paul Spur
Application Number:
JP1822197A
Publication Date:
November 13, 2000
Filing Date:
January 31, 1997
Export Citation:
Assignee:
F. Hoffman-La Rochille Age
International Classes:
A61K31/55; A61K31/551; A61K31/5517; A61P25/20; C07D487/04; C07D495/14; (IPC1-7): C07D487/04; C07D495/14
Domestic Patent References:
| JP5659776A |
Other References:
Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ，Ｖｏｌ．５６，Ｎｏ．１１，ｐ．３７１５−３７１９（１９９１）
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)