Title:
【発明の名称】イオンチャネル活性剤としてのイサチン誘導体の使用方法
Document Type and Number:
Japanese Patent JP2002531498
Kind Code:
A
Abstract:
The present invention relates to ion channel activating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as openers of SKCa and IKCa channels. In further aspects, the present invention relates to the use of these SK/IK channel activating agents for the manufacture of medicaments and pharmaceutical compositions comprising the SK/IK channel activating agents. The SK/IK channel activating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK channels, in particular respiratory diseases such as asthma, cystic fibrosis, chronic obstructive pulmonary disease and rhinorrhea, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, traumatic brain injury, psychosis, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labor, baldness, cancer, and immune suppression.
Inventors:
Jensen Bo Skerning
Jergensen Chino Dealing
Earring Philip Kay
Christopher Sen Parle
Strobec Dorte
Toy Bar Rene
Olesen Seiren Peter
Jergensen Chino Dealing
Earring Philip Kay
Christopher Sen Parle
Strobec Dorte
Toy Bar Rene
Olesen Seiren Peter
Application Number:
JP2000586327A
Publication Date:
September 24, 2002
Filing Date:
December 03, 1999
Export Citation:
Assignee:
NEUROSEARCH A/S
International Classes:
A61K31/403; A61K31/496; A61P1/00; A61P1/04; A61P1/12; A61P3/10; A61P5/48; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/00; A61P13/10; A61P13/12; A61P15/00; A61P15/12; A61P17/14; A61P21/00; A61P25/00; A61P25/06; A61P25/18; A61P25/28; A61P27/16; A61P35/00; A61P37/06; A61P43/00; A61K31/404; C07D209/60; (IPC1-7): A61K31/404; A61K31/403; A61K31/496; A61P1/00; A61P1/04; A61P1/12; A61P3/10; A61P5/48; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/00; A61P13/10; A61P13/12; A61P15/00; A61P15/12; A61P17/14; A61P21/00; A61P25/06; A61P25/18; A61P25/28; A61P27/16; A61P35/00; A61P37/06; A61P43/00
Domestic Patent References:
| JPH08333336A | 1996-12-17 | |||
| JPH06228092A | 1994-08-16 | |||
| JPH08333336A | 1996-12-17 | |||
| JPH06228092A | 1994-08-16 |
Other References:
JPN6010023719, ＤＺＹＵＢＥＮＫＯ，Ｖ．Ｇ． ｅｔ ａｌ．, "Ｔｒｉ− ａｎｄ ｔｅｔｒａａｌｋｙｌｉｎｄｏｌｏ［３，２−ｄ］ｔｈｉａｚｏｌｅｓ ａｎｄ ｔｈｅｉｒ ｄｅｒｉｖａｔｉｖｅｓ", Ｚｈｕｒｎａｌ Ｏｒｇａｎｉｃｈｅｓｋｏｉ Ｋｈｉｍｉｉ, 1987, Ｖｏｌ．２３， Ｎｏ．３, ｐ．６３１−６３７
Attorney, Agent or Firm:
Mitsufumi Ezaki (3 others)